A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20986 |
| Swiss-prot Accession number | P16471 (Sequence in FASTA format) |
| Description | Prolactin receptor precursor (PRL-R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; Single-pass type I membrane protein. Secreted. Note=Isoform 7 |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains. |
| Tissue Specificity | Expressed in breast, placenta, kidney, liver and pancreas. |
| Post translational modification | N/A |
| Function | This is a receptor for the anterior pituitary hormone prolactin. Isoforms 4 and 6 are unable to transduce prolactin signaling. |
| Protein Length | 622 Amino acids |
| Molecular weight | 69506 |
| Domain Name | fn3 |
| References | 1 PubMed abstract 2558309 2 PubMed abstract 10585417 3 PubMed abstract 10084611 4 PubMed abstract 11518703 5 PubMed abstract 12351696 6 PubMed abstract 12580759 7 PubMed abstract 15489334 8 PubMed abstract 7768908 9 PubMed abstract 16740656 10 PubMed abstract 7984244 |
| Hormone | P01236 Detail in HMRbase |
| Gene ID | 5618 |
| PDB ID | 1BP3 3D48 |
| Drugpedia | wiki |
| Comments |