A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21228 |
| Swiss-prot Accession number | P17672 (Sequence in FASTA format) |
| Description | RecName: Ecdysone-induced protein 75B, isoform A;E75-B;Alternative Name: Nuclear receptor subfamily 1 group D member 3, isoform A; |
| Source organism | Drosophila melanogaster (Fruit fly) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
| Subcellular location | Nucleus (Potential) |
| Developmental Stage | In mid instar larvae salivary glands, levels are low during puff stage 1, increase during puff stages 2-4 and diminish from stage 5 onwards. In prepupae, isoform A is the predominant form during puff stage 19 and the transition to stage 20. By stage 3 it is present in the gut, Malpighian tubules and the fat body, levels persist beyond stage 11. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone. |
| Protein Length | 1355 Amino acids |
| Molecular weight | 147171 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2110921 2 PubMed abstract 10731132 3 PubMed abstract 12537572 4 PubMed abstract 8223281 |
| Hormone | Detail in HMRbase |
| Gene ID | 39999 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |