A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20766 |
| Swiss-prot Accession number | P18089 (Sequence in FASTA format) |
| Description | Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2Badrenoreceptor) (Alpha-2 adrenergic receptor subtype C2). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. |
| Protein Length | 450 Amino acids |
| Molecular weight | 49954 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 2164221 2 PubMed abstract 2172775 3 PubMed abstract 11056163 4 PubMed abstract 15037199 5 Kopatz S.A., Aronstam R.S., Sharma S.V.; "Isolation of complete coding sequence for adrenergic receptor alpha2B (ADRA2B)."; Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases. 6 Rieder M.J., Johanson E.J., da Ponte S.H., Hastings N.C., Ahearn M.O.,Bertucci C.B., Wong M.W., Yi Q., Nickerson D.A.; "SeattleSNPs. NHLBI HL66682 program for genomic applications, UW-FHCRC, Seattle, WA (URL: http://pga.gs.washington.edu)."; Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 15815621 8 PubMed abstract 2173582 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 151 |
| PDB ID | 2CVA |
| Drugpedia | wiki |
| Comments |