A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20992 |
| Swiss-prot Accession number | P20395 (Sequence in FASTA format) |
| Description | Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats. |
| Tissue Specificity | Sertoli cells and ovarian granulosa cells. |
| Post translational modification | N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. |
| Function | Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. |
| Protein Length | 692 Amino acids |
| Molecular weight | 77681 |
| Domain Name | N/A |
| References | 1 PubMed abstract 2126341 2 PubMed abstract 1738373 3 PubMed abstract 7776966 4 PubMed abstract 2126341 5 PubMed abstract 1738373 6 PubMed abstract 7776966 |
| Hormone | P11962 Detail in HMRbase P18427 Detail in HMRbase |
| Gene ID | 25449 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |