A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21002 |
| Swiss-prot Accession number | P30082 (Sequence in FASTA format) |
| Description | Glucagon receptor precursor (GL-R). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 485 Amino acids |
| Molecular weight | 55038 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 8384375 2 PubMed abstract 8384842 3 PubMed abstract 8082779 4 PubMed abstract 8384375 5 PubMed abstract 8384842 6 PubMed abstract 8082779 |
| Hormone | P06883 Detail in HMRbase |
| Gene ID | 24953 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |