A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21004 |
| Swiss-prot Accession number | P30551 (Sequence in FASTA format) |
| Description | Cholecystokinin type A receptor (CCK-A receptor) (CCK-AR)(Cholecystokinin-1 receptor) (CCK1-R). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Pancreas and brain. Also expressed in the gastrointestinal system and vagus nerve. |
| Post translational modification | N/A |
| Function | Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 444 Amino acids |
| Molecular weight | 49657 |
| Domain Name | N/A |
| References | 1 PubMed abstract 1313582 2 PubMed abstract 7654260 3 PubMed abstract 12916469 4 PubMed abstract 8024583 5 PubMed abstract 1313582 6 PubMed abstract 7654260 7 PubMed abstract 12916469 8 PubMed abstract 8024583 |
| Hormone | P01355 Detail in HMRbase |
| Gene ID | 24889 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |