A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21006 |
| Swiss-prot Accession number | P30553 (Sequence in FASTA format) |
| Description | Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR)(Cholecystokinin-2 receptor) (CCK2-R). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Parietal cells, pancreas, brain and various neoplastic tissues. |
| Post translational modification | N/A |
| Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 452 Amino acids |
| Molecular weight | 48957 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1528881 2 PubMed abstract 1528881 |
| Hormone | P01355 Detail in HMRbase P04563 Detail in HMRbase |
| Gene ID | 25706 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |