A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21010 |
| Swiss-prot Accession number | P30872 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 1 (SS1R) (SRIF-2). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach. |
| Post translational modification | N/A |
| Function | Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. |
| Protein Length | 391 Amino acids |
| Molecular weight | 42686 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1346068 2 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 15489334 4 PubMed abstract 10734105 5 PubMed abstract 1346068 6 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 15489334 8 PubMed abstract 10734105 |
| Hormone | P61278 Detail in HMRbase |
| Gene ID | 6751 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |