A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21015 |
| Swiss-prot Accession number | P30936 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 3 (SS3R) (SSR-28). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein (By similarity). Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Densely expressed in cerebellum and in moderate levels in the amygdala, cortex, striatum, spleen, liver, pituitary. |
| Post translational modification | Phosphorylated. Phosphorylation increases upon somatostatin binding. |
| Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. |
| Protein Length | 428 Amino acids |
| Molecular weight | 47151 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1279674 2 PubMed abstract 9295322 3 PubMed abstract 1279674 4 PubMed abstract 9295322 |
| Hormone | P60042 Detail in HMRbase |
| Gene ID | 171044 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |