A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21026 |
| Swiss-prot Accession number | P32238 (Sequence in FASTA format) |
| Description | Cholecystokinin type A receptor (CCK-A receptor) (CCK-AR)(Cholecystokinin-1 receptor) (CCK1-R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 428 Amino acids |
| Molecular weight | 47841 |
| Domain Name | N/A |
| References | 1 PubMed abstract 8503909 2 PubMed abstract 8343165 3 PubMed abstract 7557108 4 PubMed abstract 10682840 5 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15489334 7 PubMed abstract 10555959 8 PubMed abstract 11300760 9 PubMed abstract 8503909 10 PubMed abstract 8343165 11 PubMed abstract 7557108 12 PubMed abstract 10682840 13 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 14 PubMed abstract 15489334 15 PubMed abstract 10555959 16 PubMed abstract 11300760 |
| Hormone | P06307 Detail in HMRbase |
| Gene ID | 886 |
| PDB ID | 1D6G 1HZN 1PB2 |
| Drugpedia | wiki |
| Comments |