A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21027 |
| Swiss-prot Accession number | P32239 (Sequence in FASTA format) |
| Description | Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR)(Cholecystokinin-2 receptor) (CCK2-R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 447 Amino acids |
| Molecular weight | 48419 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7681836 2 PubMed abstract 1280419 3 PubMed abstract 8415658 4 PubMed abstract 8349705 5 Tate S.N., Gray J., Denyer J., Stolz M., Foord S., Lee M.G.; Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases. 6 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 7 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 8 PubMed abstract 11926817 9 PubMed abstract 7681836 10 PubMed abstract 1280419 11 PubMed abstract 8415658 12 PubMed abstract 8349705 13 Tate S.N., Gray J., Denyer J., Stolz M., Foord S., Lee M.G.; Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases. 14 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 15 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 16 PubMed abstract 11926817 |
| Hormone | P01350 Detail in HMRbase P06307 Detail in HMRbase |
| Gene ID | 887 |
| PDB ID | 1L4T |
| Drugpedia | wiki |
| Comments |