A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21040 |
| Swiss-prot Accession number | P35378 (Sequence in FASTA format) |
| Description | Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats. |
| Tissue Specificity | N/A |
| Post translational modification | N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone (By similarity). |
| Function | Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. |
| Protein Length | 692 Amino acids |
| Molecular weight | 77769 |
| Domain Name | N/A |
| References | 1 PubMed abstract 10330114 2 PubMed abstract 16141072 3 PubMed abstract 1459341 4 PubMed abstract 10330114 5 PubMed abstract 16141072 6 PubMed abstract 1459341 |
| Hormone | P01216 Detail in HMRbase Q60687 Detail in HMRbase |
| Gene ID | 14309 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |