A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21045 |
| Swiss-prot Accession number | P47798 (Sequence in FASTA format) |
| Description | Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropinreceptor) (Melanocortin receptor 1) (MC1-R) (BDF3). |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Highly expressed in the testis. |
| Post translational modification | N/A |
| Function | Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis. |
| Protein Length | 317 Amino acids |
| Molecular weight | 34916 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8034052 2 PubMed abstract 8661706 3 PubMed abstract 10628296 4 Kriegesmann B., Brenig B., Dierkes B., Jansen S.; "A new melanocortin 1-receptor allele is coupled with Agouti coatcolour pattern in Holstein cattle."; Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 8034052 6 PubMed abstract 8661706 7 PubMed abstract 10628296 8 Kriegesmann B., Brenig B., Dierkes B., Jansen S.; "A new melanocortin 1-receptor allele is coupled with Agouti coatcolour pattern in Holstein cattle."; Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases. |
| Hormone | P01190 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |