A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21048 |
| Swiss-prot Accession number | P47871 (Sequence in FASTA format) |
| Description | Glucagon receptor precursor (GL-R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 477 Amino acids |
| Molecular weight | 54009 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 7507321 2 PubMed abstract 8144028 3 PubMed abstract 15489334 4 PubMed abstract 8020989 5 PubMed abstract 7589886 6 PubMed abstract 7507321 7 PubMed abstract 8144028 8 PubMed abstract 15489334 9 PubMed abstract 8020989 10 PubMed abstract 7589886 11 PubMed abstract 7507321 12 PubMed abstract 8144028 13 PubMed abstract 15489334 14 PubMed abstract 8020989 15 PubMed abstract 7589886 |
| Hormone | P01275 Detail in HMRbase |
| Gene ID | 2642 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |