A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 10033 |
| Swiss-prot Accession number | P51918 (Sequence in FASTA format) |
| Description | Progonadoliberin-1 precursor (Progonadoliberin I) [Contains:Gonadoliberin-1 (Gonadoliberin I) (Luteinizing hormone-releasinghormone I) (LH-RH I) (Gonadotropin-releasing hormone I) (GnRH-I)(Luliberin I); GnRH-associated peptide 1 (GnRH-associated peptide I)]. |
| Source organism | Haplochromis burtoni (Burton's mouthbrooder) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Labroidei;Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini;Astatotilapia. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the GnRH family. |
| Tissue Specificity | Synthesized in preoptic neurons and is transported to the pituitary in the preoptic-hypophyseal axons |
| Post translational modification | N/A |
| Function | Stimulates the secretion of gonadotropins. May be responsible for the regulation of the hypothalamic-pituitary-gonadal axis |
| Protein Length | 94 Amino acids |
| Molecular weight | 10382 |
| References | 1 PubMed abstract 7667296 2 PubMed abstract 9843638 3 PubMed abstract 7644702 |
| Domain Name | N/A |
| Hormone Name | Gonadoliberin-1 |
| Mature Hormone Sequence | QHWSYGLSPG |
| Position of mature hormone in Pre-Hormone protein | 10 Residues from position (23-32) |
| Receptor | Q5UKX6 Detail in HMRbase Q90YM3 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |