A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11492 |
| Swiss-prot Accession number | P62969 (Sequence in FASTA format) |
| Description | Thyroliberin (Thyrotropin-releasing hormone) (TRH) (Thyrotropin-releasing factor) (TRF) (TSH-releasing factor) (Protirelin). |
| Source organism | Ovis aries (Sheep) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the TRH family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems |
| Protein Length | 3 Amino acids |
| Molecular weight | 380 |
| References | 1 Desiderio D.M. Jr., Burgus R., Dunn T.F., Vale W., Guillemin R.,Ward D.N.; "The elucidation of the primary structure of the hypothalamic thyroidstimulating hormone releasing factor of ovine origin by means of massspectrometry."; Org. Mass Spectrom. 5:221-228(1971).
2 PubMed abstract 4985794 |
| Domain Name | N/A |
| Hormone Name | Thyroliberin |
| Mature Hormone Sequence | QHP |
| Position of mature hormone in Pre-Hormone protein | 3 Residues from position (1-3) |
| Receptor | Q28596
Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |