A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20013 |
| Swiss-prot Accession number | P79266 (Sequence in FASTA format) |
| Description | Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR)(Cholecystokinin-2 receptor) (CCK2-R). |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 454 Amino acids |
| Molecular weight | 48781 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8851180 2 Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 8851180 4 Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. |
| Hormone | P01352 Detail in HMRbase P41520 Detail in HMRbase |
| Gene ID | 281665 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |