A database of hormones and their receptors |
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| HMRbase accession number | 10005 |
| Swiss-prot Accession number | P81278 (Sequence in FASTA format) |
| Description | Prolactin-releasing peptide precursor (PrRP) (Prolactin-releasinghormone) [Contains: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]. |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | N/A |
| Tissue Specificity | Widely expressed, with highest levels in medulla oblongata and hypothalamus |
| Post translational modification | N/A |
| Function | Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL |
| Protein Length | 83 Amino acids |
| Molecular weight | 9215 |
| References | 1 PubMed abstract 9607765 2 PubMed abstract 11178959 3 Anderson S.T., Kokay I.C., Lang T., Grattan D.R., Curlewis J.D.; "Quantitation of prolactin-releasing peptide (PrRP) mRNA expression inspecific brain regions during the rat oestrous cycle and inlactation."; Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 10498338 |
| Domain Name | N/A |
| Hormone Name | Prolactin-releasing peptide PrRP31 |
| Mature Hormone Sequence | SRAHQHSMETRTPDINPAWYTGRGIRPVGRF |
| Position of mature hormone in Pre-Hormone protein | 31 Residues from position (22-52) |
| Receptor | Q64121
Detail in HMRbase |
| Gene ID | 63850 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 10307 |
| Swiss-prot Accession number | P81278 (Sequence in FASTA format) |
| Description | Prolactin-releasing peptide precursor (PrRP) (Prolactin-releasinghormone) [Contains: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]. |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | N/A |
| Tissue Specificity | Widely expressed, with highest levels in medulla oblongata and hypothalamus |
| Post translational modification | N/A |
| Function | Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL |
| Protein Length | 83 Amino acids |
| Molecular weight | 9215 |
| References | 1 PubMed abstract 9607765 2 PubMed abstract 11178959 3 Anderson S.T., Kokay I.C., Lang T., Grattan D.R., Curlewis J.D.; "Quantitation of prolactin-releasing peptide (PrRP) mRNA expression inspecific brain regions during the rat oestrous cycle and inlactation."; Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 10498338 |
| Domain Name | N/A |
| Hormone Name | Prolactin-releasing peptide PrRP20 |
| Mature Hormone Sequence | TPDINPAWYTGRGIRPVGRF |
| Position of mature hormone in Pre-Hormone protein | 20 Residues from position (33-52) |
| Receptor | Q64121
Detail in HMRbase |
| Gene ID | 63850 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |