A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20343 |
| Swiss-prot Accession number | Q13639 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 4 receptor (5-HT-4) (Serotonin receptor 4) (5-HT4). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Protein Length | 388 Amino acids |
| Molecular weight | 43761 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 9603189 2 Van den Wyngaert I., Gommeren W., Jurzak M., Verhasselt P., Gordon R.,Leysen J., Luyten W., Bender E.; "Cloning and expression of 5-HT4 receptor species and splicevariants."; Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 9351641 4 PubMed abstract 10220570 5 Vilaro M.T., Domenech T., Palacios J.M., Mengod G.; "Cloning and characterization of multiple human 5-HT4 receptorvariants including a novel variant that lacks the alternativelyspliced C-terminal exon."; Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15489334 7 PubMed abstract 10646498 8 PubMed abstract 7656980 |
| Hormone | Detail in HMRbase |
| Gene ID | 3360 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |