A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21092 |
| Swiss-prot Accession number | Q49LX6 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 2 (SS2R). |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Cell membrane; multi-pass membrane protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels (By similarity). |
| Protein Length | 369 Amino acids |
| Molecular weight | 41293 |
| Domain Name | 7tm_1 |
| References | 1 Liew C.W., Richter D., Kreienkamp H.-J.; "Cloning of somatostatin receptors from Canis familiaris."; Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
2 Liew C.W., Richter D., Kreienkamp H.-J.; "Cloning of somatostatin receptors from Canis familiaris."; Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. |
| Hormone | P49670 Detail in HMRbase |
| Gene ID | 403472 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |