A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21109 |
| Swiss-prot Accession number | Q61606 (Sequence in FASTA format) |
| Description | Glucagon receptor precursor (GL-R). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Expressed predominantly in liver, kidney, adrenal, lung and stomach, while lower levels of expression are detected in brown and white adipose tissue, cerebellum, duodenum and heart. |
| Post translational modification | N/A |
| Function | This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 485 Amino acids |
| Molecular weight | 54872 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 7590348 2 PubMed abstract 8156917 3 PubMed abstract 7590348 4 PubMed abstract 8156917 |
| Hormone | P55095 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |