| HMRbase accession number | 22957 |
| Swiss-prot Accession number | Q62959 (Sequence in FASTA format) |
| Description | Leptin receptor;LEP-R;Alternative Name: OB receptor;OB-R;Alternative Name: CD_antigen=CD295;Precursor |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. |
| Tissue Specificity | Isoform B is expressed in kidney, liver, lung, ovary, spleen and uterus. Increased level in uterus during gestation. Isoform F is expressed at high levels in liver and spleen and less in brain, stomach, kidney, thymus, heart, lung and hypothalamus. |
| Post translational modification | On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. |
| Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3 (By similarity). Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). Isoform A may act to transport leptin to the cerebrospinal fluid. The putative soluble isoform E could function as a transport protein. |
| Protein Length | 1162 Amino acids |
| Molecular weight | 130833 |
| Domain Name | fn3 Lep_receptor_Ig |
| References | 1 PubMed abstract 8673096
2 PubMed abstract 8702432
3 PubMed abstract 8769097
4 PubMed abstract 8630068
5 PubMed abstract 8772180
6 PubMed abstract 9268737
7 PubMed abstract 8690163
|
| Hormone | P50596 Detail in HMRbase
|
| Gene ID | 24536 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors