A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 22995 |
| Swiss-prot Accession number | Q6AXS4 (Sequence in FASTA format) |
| Description | Renin receptor;Alternative Name: Renin/prorenin receptor;Alternative Name: ATPase, H(+)-transporting, lysosomal accessory protein 2;Alternative Name: ATPase, H(+)-transporting, lysosomal-interacting protein 2;Precursor |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Membrane; Single-pass type I membrane protein (Potential) |
| Developmental Stage | N/A |
| Similarity | N/A |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated (By similarity). |
| Function | Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). |
| Protein Length | 350 Amino acids |
| Molecular weight | 39082 |
| Domain Name | Renin_r |
| References | 1 PubMed abstract 15489960 2 PubMed abstract 15489334 |
| Hormone | P08424 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |