A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21155 |
| Swiss-prot Accession number | Q8SPP9 (Sequence in FASTA format) |
| Description | Thyrotropin receptor precursor (TSH-R) (Thyroid-stimulating hormonereceptor). |
| Source organism | Sus scrofa (Pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 8 LRR (leucine-rich) repeats. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5) (By similarity). |
| Protein Length | 764 Amino acids |
| Molecular weight | 86644 |
| Domain Name | 7tm_1 LRR_1 |
| References | 1 PubMed abstract 12880144 2 Melen L.B., McNamara E.M., Hennen G.P., Igout A.; "Porcine thyroid stimulating hormone receptor (TSHR) mRNA variant."; Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases. |
| Hormone | P01219 Detail in HMRbase P01224 Detail in HMRbase |
| Gene ID | 397560 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |