A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11244 |
| Swiss-prot Accession number | P01150 (Sequence in FASTA format) |
| Description | Thyroliberin precursor [Contains: Prothyroliberin; Thyroliberin(Thyrotropin-releasing hormone) (TRH) (Thyrotropin-releasing factor)(TRF) (TSH-releasing factor) (Protirelin)]. |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the TRH family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems |
| Protein Length | 255 Amino acids |
| Molecular weight | 29284 |
| References | 1 PubMed abstract 3079917 2 PubMed abstract 2903153 3 PubMed abstract 2497670 4 Mandel G., Goodman R.H.; "Using the brain to screen cloned genes."; Trends Neurosci. 10:101-104(1987). 5 PubMed abstract 2119297 |
| Domain Name | TRH |
| Hormone Name | Thyroliberin |
| Mature Hormone Sequence | QHP |
| Position of mature hormone in Pre-Hormone protein | 3 Residues from position (77-79) |
| Receptor | Q01717 Detail in HMRbase Q9R297 Detail in HMRbase |
| Gene ID | 25569 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |