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Peptide Hormone

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HMRbase accession number11285
Swiss-prot Accession numberP01193 (Sequence in FASTA format)
DescriptionCorticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin].
Source organismMus musculus (Mouse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular locationN/A
Developmental StageN/A
Similarity Belongs to the POMC family.
Tissue SpecificityACTH and MSH are produced by the pituitary gland
Post translational modification Specific enzymatic cleavages at paired basic residues yield the different active peptides.
Function MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes
Protein Length235 Amino acids
Molecular weight26707
References1  PubMed abstract 6303853
2  PubMed abstract 6308009
3  PubMed abstract 16141072
4  PubMed abstract 15489334
5  PubMed abstract 2536749
6  PubMed abstract 1689057
7  PubMed abstract 221916
8  PubMed abstract 6303853
9  PubMed abstract 6308009
10  PubMed abstract 16141072
11  PubMed abstract 15489334
12  PubMed abstract 2536749
13  PubMed abstract 1689057
14  PubMed abstract 221916
Domain NameNPP  ACTH_domain  Op_neuropeptide  
Hormone NameMelanotropin alpha (Alpha-MSH)
Mature Hormone SequenceSYSMEHFRWGKPV
Position of mature hormone in Pre-Hormone protein13 Residues from position (124-136)
ReceptorQ64326   Detail in HMRbase   
Q01727    Detail in HMRbase   
Gene ID18976      
PDB IDN/A
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