A database of hormones and their receptors

Peptide Hormone

HMRbase accession number	10043
Swiss-prot Accession number	P82965 (Sequence in FASTA format)
Description	Antidiuretic factor A (ADFa) (ADF) (Antidiuretic hormone A) (ADHA).
Source organism	Tenebrio molitor (Yellow mealworm)
Taxonomical Classification	Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;Tenebrionidae; Tenebrio.
Subcellular location	Secreted
Developmental Stage	N/A
Similarity	To T.molitor cuticular protein LPCP29 C-terminal region.
Tissue Specificity	N/A
Post translational modification	N/A
Function	Strong inhibitor of fluid secretion by the Malpighian tubules. Uses cGMP as a second messenger and inhibits fluid production by decreasing cAMP concentration. Reduces isosmotic fluid secretion by inhibiting electroneutral and non-conductive transport pathways. Reverses the stimulatory effect of diuretic hormone I
Protein Length	14 Amino acids
Molecular weight	1543
References	1 PubMed abstract 11756661 2 PubMed abstract 11893763 3 PubMed abstract 15235016 4 PubMed abstract 11756661 5 PubMed abstract 11893763 6 PubMed abstract 15235016
Domain Name	N/A
Hormone Name	Antidiuretic factor A
Mature Hormone Sequence	VVNTPGHAVSYHVY
Position of mature hormone in Pre-Hormone protein	14 Residues from position (1-14)
Receptor	N/A
Gene ID	N/A
PDB ID	N/A
Drugpedia	wiki
Comments	!Receptor for this Hormone are either unknown or have not yet been curated