A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10109 |
| Swiss-prot Accession number | Q9BEF8 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 117 Amino acids |
| Molecular weight | 13007 |
| References | 1 Tomasetto C., Wendling C., Rio M.-C., Poitras P.; "Identification of cDNA encoding MTLRP/ghrelin precursor from dogfundus."; Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
2 Doi K., Kojima M., Hosoda H., Kaiya H., Matsuo H., Kangawa K.; "Dog ghrelin."; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFDVGIKLSGPQYHQHGQAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | N/A |
| Gene ID | 403587 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |