A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10582 |
| Swiss-prot Accession number | P14944 (Sequence in FASTA format) |
| Description | Crustacean hyperglycemic hormones precursor [Contains: CHH precursor-related peptide (CPRP); Crustacean hyperglycemic hormone (CHH)]. |
| Source organism | Carcinus maenas (Common shore crab) (Green crab) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca;Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;Eubrachyura; Portunoidea; Portunidae; Carcinus. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the arthropod CHH/MIH/GIH/VIH hormone family. |
| Tissue Specificity | Produced by the medulla terminalis X-organ in the eyestalks and transported to the sinus gland where they are stored and released |
| Post translational modification | The N-terminus is blocked only in isoform CHH-II but not in isoform CHH-I. |
| Function | Hormone found in the sinus gland of isopods and decapods which controls the blood sugar level. Has a secretagogue action over the amylase released from the midgut gland. May act as a stress hormone and may be involved in the control of molting and reproduction |
| Protein Length | 142 Amino acids |
| Molecular weight | 16138 |
| References | 1 PubMed abstract 2806562 2 PubMed abstract 2792364 3 PubMed abstract 1788131 4 PubMed abstract 8841399 |
| Domain Name | Crust_neurohorm Crust_neuro_H |
| Hormone Name | Crustacean hyperglycemic hormone |
| Mature Hormone Sequence | QIYDTSCKGVYDRALFNDLEHVCDDCYNLYRTSYVASACRSNCYSNLVFRQCMDDLLMMDEFDQYARKVQMV |
| Position of mature hormone in Pre-Hormone protein | 72 Residues from position (67-138) |
| Receptor | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |