A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 11290 |
| Swiss-prot Accession number | P01197 (Sequence in FASTA format) |
| Description | Corticotropin (Adrenocorticotropic hormone) (ACTH) [Contains:Melanotropin alpha (Alpha-MSH); Corticotropin-like intermediarypeptide (CLIP)]. |
| Source organism | Squalus acanthias (Spiny dogfish) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;Elasmobranchii; Squalea; Hypnosqualea; Squaliformes; Squaloidei;Squalidae; Squalus. |
| Subcellular location | N/A |
| Developmental Stage | N/A |
| Similarity | Belongs to the POMC family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes |
| Protein Length | 39 Amino acids |
| Molecular weight | 4686 |
| References | 1 PubMed abstract 4375977 2 PubMed abstract 5476715 3 PubMed abstract 4375978 4 PubMed abstract 4375977 5 PubMed abstract 5476715 6 PubMed abstract 4375978 |
| Domain Name | ACTH_domain |
| Hormone Name | Melanotropin alpha (Alpha-MSH) |
| Mature Hormone Sequence | SYSMEHFRWGKPM |
| Position of mature hormone in Pre-Hormone protein | 1 Residues from position (1-13) |
| Receptor | Q6Q488
Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |