A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11367 |
| Swiss-prot Accession number | P04652 (Sequence in FASTA format) |
| Description | Thyrotropin subunit beta precursor (Thyroid-stimulating hormonesubunit beta) (TSH-beta) (TSH-B) (Thyrotropin beta chain). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the glycoprotein hormones subunit beta family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Indispensable for the control of thyroid structure and metabolism |
| Protein Length | 138 Amino acids |
| Molecular weight | 15505 |
| References | 1 PubMed abstract 6086256 2 PubMed abstract 3839124 3 PubMed abstract 3017658 4 PubMed abstract 3027091 5 PubMed abstract 15489334 6 Kato Y., Ezashi T., Hirai T., Kato T.; "Strain difference in nucleotide sequences of rat glycoprotein hormonesubunit cDNAs and gene fragment."; Zool. Sci. 7:877-885(1990). |
| Domain Name | Cys_knot |
| Hormone Name | Thyroid-stimulating hormone subunit beta (TSH-B) (Thyrotropin beta chain) |
| Mature Hormone Sequence | FCIPTEYMMYVDRRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFTYRTVEIPGCPHHVAPYFSYPVALSCKCGKCNTDYSDCTHEAVKTNYCTKPQTFY |
| Position of mature hormone in Pre-Hormone protein | 112 Residues from position (21-132) |
| Receptor | P21463
Detail in HMRbase |
| Gene ID | 25653 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |