A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 11580 |
| Swiss-prot Accession number | P52115 (Sequence in FASTA format) |
| Description | Renin; EC=3.4.23.15;Alternative Name: Angiotensinogenase;Precursor |
| Source organism | Ovis aries (Sheep) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular location | Secreted (By similarity). Membrane (By similarity). Note=Associated to membranes via binding to ATP6AP2 (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the peptidase A1 family. |
| Tissue Specificity | Kidney |
| Post translational modification | N/A |
| Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Protein Length | 400 Amino acids |
| Molecular weight | 44016 |
| References | 1 PubMed abstract 1543532 |
| Domain Name | A1_Propeptide Asp |
| Hormone Name | Renin |
| Mature Hormone Sequence | |
| Position of mature hormone in Pre-Hormone protein | |
| Receptor | N/A |
| Gene ID | 443310 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |