A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20038 |
| Swiss-prot Accession number | Q9BY15 (Sequence in FASTA format) |
| Description | EGF-like module-containing mucin-like hormone receptor-like 3precursor (EGF-like module-containing mucin-like receptor EMR3). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein. Subunit alpha: Secreted protein; extracellular space. Note=A soluble form is also detected (alpha subunit) |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 2 EGF-like domains. Contains 1 GPS domain. |
| Tissue Specificity | Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages. |
| Post translational modification | Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit (By similarity). |
| Function | Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes- derived macrophages and activated neutrophils. |
| Protein Length | 652 Amino acids |
| Molecular weight | 72593 |
| Domain Name | 7tm_2 GPS EGF_CA |
| References | 1 PubMed abstract 11279179 2 PubMed abstract 12975309 3 PubMed abstract 17081983 |
| Hormone | N/A |
| Gene ID | 84658 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |