A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20041 |
| Swiss-prot Accession number | P11474 (Sequence in FASTA format) |
| Description | Steroid hormone receptor ERR1 (Estrogen-related receptor, alpha) (ERR-alpha) (Estrogen receptor-like 1). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. |
| Protein Length | 519 Amino acids |
| Molecular weight | 55440 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 3267207 2 PubMed abstract 8621448 3 PubMed abstract 8224847 4 PubMed abstract 9271417 5 PubMed abstract 15302935 |
| Hormone | N/A |
| Gene ID | 2101 |
| PDB ID | 1XB7 2PJL 3D24 |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |