A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20061 |
| Swiss-prot Accession number | Q9W539 (Sequence in FASTA format) |
| Description | Hormone receptor 4 (dHR4). |
| Source organism | Drosophila melanogaster (Fruit fly) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | During L2 and L3 stages, strong constitutive expression is seen in the ring gland. Lower expression is detected in specific neurons of the central nervous system (CNS) (at protein level). |
| Post translational modification | N/A |
| Function | Coordinates growth and maturation by mediating endocrine responses to the attainment of critical weight during larval development. Plays a central role in the genetic cascades triggered by the steroid hormone ecdysone at the onset of metamorphosis, acting as both a repressor of the early ecdysone- induced regulatory genes and an inducer of the ftz-f1 midprepupal competence factor. |
| Protein Length | 1518 Amino acids |
| Molecular weight | 162655 |
| Domain Name | zf-C4 Hormone_recep |
| References | 1 PubMed abstract 15935763 2 PubMed abstract 10731132 3 PubMed abstract 12537572 4 PubMed abstract 10731137 |
| Hormone | N/A |
| Gene ID | 31162 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |