A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20163 |
| Swiss-prot Accession number | Q03181 (Sequence in FASTA format) |
| Description | Peroxisome proliferator-activated receptor delta (PPAR-delta) (PPAR-beta) (Nuclear hormone receptor 1) (NUC1) (NUCI). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Ubiquitous with maximal levels in placenta and skeletal muscle. |
| Post translational modification | N/A |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Decreases expression of NPC1L1 once activated by a ligand. |
| Protein Length | 441 Amino acids |
| Molecular weight | 49903 |
| Domain Name | zf-C4 Hormone_recep |
| References | 1 PubMed abstract 1333051 2 PubMed abstract 10851270 3 Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S.,Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Departmentof Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 14574404 5 PubMed abstract 15489334 6 Aoto T., Ishizuka M., Kazusaka A., Fujita S.; "PPAR-delta 5'-complete cDNA fragment."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 15604518 |
| Hormone | Detail in HMRbase |
| Gene ID | 5467 |
| PDB ID | 1GWX 1Y0S 2AWH 2B50 2BAW 2ENV 2GWX 2J14 2Q5G 3D5F 3GWX |
| Drugpedia | wiki |
| Comments |