A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20167 |
| Swiss-prot Accession number | P49190 (Sequence in FASTA format) |
| Description | Parathyroid hormone receptor precursor (PTH2 receptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Expressed abundantly in brain and pancreas. Also expressed in the testis. |
| Post translational modification | N/A |
| Function | This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTHR2 may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTHR2 presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). |
| Protein Length | 550 Amino acids |
| Molecular weight | 62236 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 7797535 2 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 15489334 4 PubMed abstract 8921382 5 PubMed abstract 11861531 |
| Hormone | N/A |
| Gene ID | 5746 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |