A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20177 |
| Swiss-prot Accession number | P08689 (Sequence in FASTA format) |
| Description | Sex hormone-binding globulin precursor (SHBG) (Sex steroid-bindingprotein) (SBP) (Testis-specific androgen-binding protein) (ABP). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted protein. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis |
| Developmental Stage | In the fetal liver, expressed from day 14 to day 17 after conception. |
| Similarity | Contains 2 laminin G-like domains. |
| Tissue Specificity | Isoform 2 is only expressed in the liver. |
| Post translational modification | N/A |
| Function | Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). |
| Protein Length | 403 Amino acids |
| Molecular weight | 44533 |
| Domain Name | Laminin_G_1 Laminin_G_2 |
| References | 1 PubMed abstract 2432609 2 PubMed abstract 2840566 3 PubMed abstract 15489334 4 PubMed abstract 1702422 5 PubMed abstract 3135485 6 PubMed abstract 1855466 |
| Hormone | N/A |
| Gene ID | 24775 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |