A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20278 |
| Swiss-prot Accession number | Q90334 (Sequence in FASTA format) |
| Description | Isotocin receptor (ITR). |
| Source organism | Catostomus commersoni (White sucker) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;Catostomidae; Catostomus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed in brain, intestine, bladder, skeletal muscle, lateral line, gills and kidney. |
| Post translational modification | N/A |
| Function | Binds to isotocin. Can also be activated by vasotocin, mesotocin, oxytocin and Arg-vasopressin, although these have lower potencies than isotocin. Produces an induction of membrane chloride currents indicating that it is coupled to the inositol phosphate/calcium pathway. |
| Protein Length | 390 Amino acids |
| Molecular weight | 44504 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7656982 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |