A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20306 |
| Swiss-prot Accession number | P49144 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 1B receptor (5-HT-1B) (Serotonin receptor 1B) (5-HT1B) (5-HT-1D-beta). |
| Source organism | Oryctolagus cuniculus (Rabbit) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;Oryctolagus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated (By similarity). Palmitoylated (By similarity). |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. |
| Protein Length | 390 Amino acids |
| Molecular weight | 43496 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8543023 2 Wurch T., Cathala C., Palmer C., Valentin J.P., John G.,Colpaert F.C., Pauwels P.J.; "Molecular cloning and identification of a rabbit saphenous vein 5-HT1DB receptor gene."; Neurosci. Res. Commun. 18:155-162(1996). 3 PubMed abstract 8878052 |
| Hormone | N/A |
| Gene ID | 100009594 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |