A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20345 |
| Swiss-prot Accession number | Q62758 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 4 receptor (5-HT-4) (Serotonin receptor 4) (5-HT4). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | In brain, isoform 5-HT4S is restricted to the striatum, but isoform 5-HT4L is expressed throughout the brain, except in the cerebellum. In peripheral tissues, differential expression is also observed in the atrium of the heart where only isoform 5-HT4S is detectable. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Protein Length | 406 Amino acids |
| Molecular weight | 46107 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7796807 2 PubMed abstract 7656980 3 PubMed abstract 10220570 |
| Hormone | N/A |
| Gene ID | 25324 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |