A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20350 |
| Swiss-prot Accession number | P50406 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 6 receptor (5-HT-6) (Serotonin receptor 6). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed in several human brain regions, most prominently in the caudate nucleus. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. |
| Protein Length | 440 Amino acids |
| Molecular weight | 46954 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8522988 2 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 15489334 4 PubMed abstract 7656980 5 PubMed abstract 16094384 |
| Hormone | N/A |
| Gene ID | 3362 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |