A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20353 |
| Swiss-prot Accession number | P31388 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 6 receptor (5-HT-6) (Serotonin receptor 6) (ST-B17). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Localized exclusively in the central nervous system, predominantly in the corpus striatum but also in various limbic and cortical regions. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. |
| Protein Length | 436 Amino acids |
| Molecular weight | 46923 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7680751 2 PubMed abstract 8389146 3 Martial R.; "A novel rat serotonin (5HT6) receptor."; Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases. |
| Hormone | N/A |
| Gene ID | 64354 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |