A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20355 |
| Swiss-prot Accession number | P34969 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine 7 receptor (5-HT-7) (Serotonin receptor 7) (5-HT-X) (5HT7). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels, and isoform D is a minor isoform. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Protein Length | 479 Amino acids |
| Molecular weight | 53555 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 9084407 2 PubMed abstract 8226867 3 King M.M., Aronstam R.S., Sharma S.V.; "Isolation of cDNA coding for 5-hydroxytryptamine receptor 7,transcript variant b (HTR7B)."; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 15489334 5 PubMed abstract 9154233 |
| Hormone | N/A |
| Gene ID | 3363 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |