A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20430 |
| Swiss-prot Accession number | P32245 (Sequence in FASTA format) |
| Description | Melanocortin receptor 4 (MC4-R). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Brain, placental, and gut tissues. |
| Post translational modification | N/A |
| Function | Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase. |
| Protein Length | 332 Amino acids |
| Molecular weight | 36943 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8392067 2 PubMed abstract 7854347 3 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 15489334 5 PubMed abstract 10199800 6 PubMed abstract 11443223 7 PubMed abstract 8392067 8 PubMed abstract 7854347 9 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. 10 PubMed abstract 15489334 11 PubMed abstract 10199800 12 PubMed abstract 11443223 |
| Hormone | N/A |
| Gene ID | 4160 |
| PDB ID | 2IQP 2IQR 2IQS 2IQU 2IQV 2IQW |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |