A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20658 |
| Swiss-prot Accession number | P48039 (Sequence in FASTA format) |
| Description | Melatonin receptor type 1A (Mel-1A-R) (Mel1a melatonin receptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus. |
| Post translational modification | N/A |
| Function | High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. |
| Protein Length | 350 Amino acids |
| Molecular weight | 39375 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7946354 2 PubMed abstract 10471411 3 PubMed abstract 15489334 |
| Hormone | Detail in HMRbase |
| Gene ID | 4543 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |