A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20660 |
| Swiss-prot Accession number | P49217 (Sequence in FASTA format) |
| Description | Melatonin receptor type 1A (Mel-1A-R) (Mel1a melatonin receptor). |
| Source organism | Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Cricetidae; Cricetinae; Phodopus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | At least in the brain, more precisely in the pars tuberalis and the suprachiasmatic nucleus. |
| Post translational modification | N/A |
| Function | High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. |
| Protein Length | 353 Amino acids |
| Molecular weight | 39685 |
| Domain Name | 7tm_1 |
| References | 1 Weaver D.R., Liu C., Reppert S.M.; Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
2 PubMed abstract 7946354 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |