A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20662 |
| Swiss-prot Accession number | P49286 (Sequence in FASTA format) |
| Description | Melatonin receptor type 1B (Mel-1B-R) (Mel1b melatonin receptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed in retina and less in brain and hippocampus. |
| Post translational modification | N/A |
| Function | High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. |
| Protein Length | 362 Amino acids |
| Molecular weight | 40188 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7568007 2 PubMed abstract 10696804 3 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 15489334 |
| Hormone | N/A |
| Gene ID | 4544 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |