A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20677 |
| Swiss-prot Accession number | Q16602 (Sequence in FASTA format) |
| Description | Calcitonin gene-related peptide type 1 receptor precursor (CGRP type 1receptor) (Calcitonin receptor-like receptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Predominantly expressed in the lung and heart. |
| Post translational modification | N/A |
| Function | Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
| Protein Length | 461 Amino acids |
| Molecular weight | 52979 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 8626685 2 PubMed abstract 7818539 3 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 15340161 |
| Hormone | N/A |
| Gene ID | 10203 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |