A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 20701 |
| Swiss-prot Accession number | Q76LL8 (Sequence in FASTA format) |
| Description | Corticotropin-releasing factor receptor 1 precursor. |
| Source organism | Macaca mulatta (Rhesus macaque) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Expressed abundantly in the pituitary, cerebral cortex, hippocampus, amygdala and cerebellum. |
| Post translational modification | C-terminal Ser or Thr residues may be phosphorylated (By similarity). |
| Function | This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
| Protein Length | 415 Amino acids |
| Molecular weight | 47784 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 14761672 |
| Hormone | N/A |
| Gene ID | 574095 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |